Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease
نویسندگان
چکیده
منابع مشابه
Lewy body disease and dementia with Lewy bodies
In 1976 we reported our first autopsied case with diffuse Lewy body disease (DLBD), the term of which we proposed in 1984. We also proposed the term "Lewy body disease" (LBD) in 1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: a brain stem type, a transitional type and a diffuse type. Later, we added the cerebral type. As we have propo...
متن کاملDementia with Lewy bodies and Parkinson's disease.
Lewy bodies (LB) in the central nervous system are associated with several different clinical syndromes including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Long term follow up of PD patients finds up to 78% eventually develop dementia, most of these patients exhibiting fluctuating cognition and visual hallucinations similar to DLB and with extensive cortical LB at autopsy. a...
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Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition. We show here that Lewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stained strongly by antibodies directed against amino-terminal and carboxyl-termin...
متن کاملDementia with Lewy bodies.
The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms and those that may improve them. Neuroc...
متن کاملDementia with Lewy bodies.
DLB is one of several causes of dementia. The most common cause is Alzheimer's disease, which is an entirely separate neurodegenerative disease. Vascular dementia is the second most common cause of dementia, and here the pathological changes are due to stroke and to related changes that impair blood circulation in the brain. DLB is the third most common cause. Changes of all three disorders can...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2009
ISSN: 1750-1326
DOI: 10.1186/1750-1326-4-32